RESEARCH HIGHLIGHTS

WITS RESEARCH INSTITUTE FOR MALARIA

Vectors

  • Insecticide resistance in mosquito populations
  • Systematics and population genetics of vector mosquitoes
  • Novel methods for vector control
  • Mosquito/parasite interactions

Molecular parasitology

  • Fundamental aspects of parasite biology
  • Evolutionary aspects of Plasmodium
  • Novel parasite drug targets
  • Genetic manipulation of parasites

Antimalarial drug discovery

  • Design and evaluate antimalarial activities of synthetic and natural compounds.
  • Elucidate mechanisms of action of the compounds and interaction of novel compounds with standard antimalarial agents.
  • Determine toxicological properties and safety indices of the compounds.
  • Investigate antimalarial activity in vitro, in vivo and in phase 1 to 3 clinical trials.

Investigations of malaria transmission

in African countries and recommendations for integrated malaria control interventions:

For commercial companies operating in Senegal, Guinea Conakry, Mali, Ghana, Angola, DRC, Malawi and Tanzania

As collaborators on WHO/AFRO, WHO/TDR, MIM, Gates Foundation and Wellcome Trust funded projects in Senegal, Burkina Faso, Benin, Nigeria, Chad, Sudan, Ethiopia, Kenya, Tanzania, Malawi, Zimbabwe, Angola, Namibia, Botswana, Mozambique and Swaziland.

Collaborative research projects

with international institutions such as the Liverpool School of Tropical Medicine, London School of Hygiene & Tropical Medicine, UK; Johns Hopkins University, Notre Dame University, University of California at Davis, Tufts University, Centres for Disease Control, USA; University of Wageningen, the Netherlands; IRD and ILL, France; IMBB, Crete, Greece; Jamia Millia Islamia, India; and the Academy of Science, Czech Republic.